Paraoxonase 1 Q192R genotype and activity affect homocysteine thiolactone levels in humans
نویسندگان
چکیده
منابع مشابه
Homocysteine levels, paraoxonase 1 (PON1) activity, and cardiovascular risk.
lyzed our study population by dividing the births within each gestational age category into smaller and larger birth weights by their z score of birth weight by gestational age. Adjusting for gestational week within each category as well as year of birth, larger infants did have the best survival for any given gestational age. For 22 to 27, 28 to 32, 33 to 36, and 37 to 42 weeks, the relative r...
متن کاملUrinary excretion of homocysteine-thiolactone in humans.
BACKGROUND A metabolite of homocysteine (Hcy), the thioester Hcy-thiolactone, has been implicated in coronary heart disease in humans. Because inadvertent reactions of Hcy-thiolactone with proteins can lead to cell and tissue damage, the ability to detoxify or eliminate Hcy-thiolactone is essential for biological integrity. We examined the hypothesis that the human body eliminates Hcy-thiolacto...
متن کاملAssociation of Homocysteine, Asymmetric Dimethylarginine and L55M and Q192R Polymorphisms of Paraoxonase-1 Gene with Preeclampsia
Objective: Preeclampsia is a major cause of maternal and fetal mortality worldwide. A reliable test that would identify the "at risk" group of pregnant women is not available. Homocysteine and ADMA have been shown to be elevated in disorders characterized by endothelial dysfunction including preeclampsia. Paraoxonase 1 is though to influence serum homocysteine and to play a role in preeclampsia...
متن کاملHigh levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism.
Autism is a behaviorally defined disorder of unknown etiology that is thought to be influenced by genetic and environmental factors. High levels of homocysteine and oxidative stress are generally associated with neuropsychiatric disorders. The purpose of this study was to compare the level of homocysteine and other biomarkers in children with autism to corresponding values in age-matched health...
متن کاملParaoxonase 1 Q192R variant and clopidogrel efficacy: fact or fiction?
Clopidogrel, in combination with aspirin, is the standard of care for preventing ischemic cardiovascular events in patients with coronary artery disease, especially those who undergo percutaneous coronary intervention (PCI). Despite its widespread use, significant interindividual variability in clopidogrel response is consistently observed, and recent studies have suggested that as much as 70% ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2018
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.201800346r