Paraoxonase 1 Q192R genotype and activity affect homocysteine thiolactone levels in humans

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Homocysteine levels, paraoxonase 1 (PON1) activity, and cardiovascular risk.

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Urinary excretion of homocysteine-thiolactone in humans.

BACKGROUND A metabolite of homocysteine (Hcy), the thioester Hcy-thiolactone, has been implicated in coronary heart disease in humans. Because inadvertent reactions of Hcy-thiolactone with proteins can lead to cell and tissue damage, the ability to detoxify or eliminate Hcy-thiolactone is essential for biological integrity. We examined the hypothesis that the human body eliminates Hcy-thiolacto...

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Association of Homocysteine, Asymmetric Dimethylarginine and L55M and Q192R Polymorphisms of Paraoxonase-1 Gene with Preeclampsia

Objective: Preeclampsia is a major cause of maternal and fetal mortality worldwide. A reliable test that would identify the "at risk" group of pregnant women is not available. Homocysteine and ADMA have been shown to be elevated in disorders characterized by endothelial dysfunction including preeclampsia. Paraoxonase 1 is though to influence serum homocysteine and to play a role in preeclampsia...

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High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism.

Autism is a behaviorally defined disorder of unknown etiology that is thought to be influenced by genetic and environmental factors. High levels of homocysteine and oxidative stress are generally associated with neuropsychiatric disorders. The purpose of this study was to compare the level of homocysteine and other biomarkers in children with autism to corresponding values in age-matched health...

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ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2018

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fj.201800346r